Electroacupuncture at Acupoints Reverses Plasma Glutamate, Lipid, and LDL/VLDL in an Acute Migraine Rat Model: A (1) H NMR-Based Metabolomic Study.

作者: Gao Z, Liu X, Yu S, Zhang Q, Chen Q, Wu Q, Liu J, Sun B, Fang L, Lin J, Zhu BM, Yan X, Liang F
成果类型: 期刊论文
数据来源: ESI SCIE
发表日期: 2014
年卷期页: 2014,2014,659268
期刊名: 《Evidence-based complementary and alternative medicine : eCAM》 影响因子和分区 年份    影响因子    区号
2016    1.740        3区 2015    1.931        3区 2014    1.880        3区 2013    1.722        3区 2012    4.929        3区
英文摘要: Background. The objective of this study was to identify potential biomarkers of electroacupuncture (EA) on relieving acute migraine through metabolomic study. Methods. EA treatments were performed on both acupoints and nonacupoints on the nitroglycerin (NTG)-induced migraine rat model. NMR experiments and multivariate analysis were used for metabolomic analysis. Results. The number of head-scratching, the main ethology index of migraine rat model, was significantly increased (P < 0.01) after NTG injection. The plasma metabolic profile of model group was distinct from that of the control group. Glutamate was significantly increased (P < 0.01), whereas lipids were significantly decreased (P < 0.01) in model rats. After EA at acupoints, the metabolic profile of model rats was normalized, with decreased glutamate (P < 0.05) and increased lipids (P < 0.01). In contrast, EA at nonacupoints did not restore the metabolic profile, but with six metabolites significantly different from acupoints group. Interestingly, the number of head-scratching and glutamate level were significantly decreased (P < 0.05) after receiving EA at both acupoints and nonacupoints. Conclusions. EA at acupoints may relieve acute migraine by restoring the plasma metabolic profile and plasma glutamate, while EA at nonacupoints may modestly relieve acute migraine by decreasing plasma glutamate.
语言: United States
出版类型: Journal Article
作者地址: Clinical Acupuncture and Moxibustion Department, Second School of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, China ; Acupuncture and Tuina College, Chengdu University of TCM, Chengdu, Sichuan 610075, China. [1]
Acupuncture and Tuina College, Chengdu University of TCM, Chengdu, Sichuan 610075, China. [2]
Acupuncture and Tuina College, Chengdu University of TCM, Chengdu, Sichuan 610075, China. [3]
National Center of Biomedical Analysis, Beijing 100850, China. [4]
The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, China. [5]
Acupuncture and Tuina College, Chengdu University of TCM, Chengdu, Sichuan 610075, China. [6]
National Center of Biomedical Analysis, Beijing 100850, China. [7]
National Center of Biomedical Analysis, Beijing 100850, China. [8]
The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, China. [9]
Department of Biochemistry and Molecular Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, China. [10]
Clinical Acupuncture and Moxibustion Department, Second School of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, China. [11]
National Center of Biomedical Analysis, Beijing 100850, China. [12]
Acupuncture and Tuina College, Chengdu University of TCM, Chengdu, Sichuan 610075, China. [13]
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